-The technical term for Enagic's alkaline Kangen Water is Electrolyzed-Reduced Water (ERW).

-The acidic waters produced by a Kangen Machine are called Acidic Electrolyzed Water (AEW) or Electrolyzed Oxidized Water (EOW).

-Many studies have been conducted on ERW, AEW and EOW and its effect on health and other practical applications.

-Kangen Water contains Molecular Hydrogen (H2), which is a powerful antioxidant and has many health benefits.


Here are just a few of the research studies (in no particular order).....

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-Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.  Biochemical and Biophysical Research Communications 397, 608-613. KAWASAKI, H., GUAN, J. J. & TAMAMA, K. (2010)

- Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. Journal of Physiological Anthropology 30, 195-201.FUJITA, R., TANAKA, Y., SAIHARA, Y., YAMAKITA, M., ANDO, D. & KOYAMA, K. (2011).

- Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research 1, 18. HANAOKA, T., KAMIMURA, N., YOKOTA, T., TAKAI, S. & OHTA, S. (2011).

- Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and Biophysical Research Communications 411, 143- 9. ITOH, T., HAMADA, N., TERAZAWA, R., ITO, M., OHNO, K., ICHIHARA, M. & NOZAWA, Y. (2011).

- Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.Investigative Ophthalmology and Visual Science 52, 427-33.KUBOTA, M., SHIMMURA, S., KUBOTA, S., MIYASHITA, H., KATO, N., NODA, K., OZAWA, Y., USUI, T., ISHIDA, S., UMEZAWA, K., KURIHARA, T. & TSUBOTA, K. (2011).

- Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats.

Acta Neurochir Suppl 111, 237-41.LEKIC, T., MANAENKO, A., ROLLAND, W., FATHALI, N., PETERSON, M., TANG, J. & ZHANG, J. H. (2011).

- Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Internal Medicine 51, 1309-13.TAKEUCHI, S., WADA, K., NAGATANI, K., OSADA, H., OTANI, N. & NAWASHIRO, H. (2012).

- Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond) 9, 2.XU, Z., ZHOU, J., CAI, J., ZHU, Z., SUN, X. & JIANG, C. (2012)


- Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics 2, 257-260.. T. KASHIWAGI, T. H., S. KABAYAMA, M. TAKAKI, K. TERUYA, Y. KATAKURA, K. OTUBO, S. MORISAWA, S. SHIRAHATA. (2005).

- Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and Biophysical Research Communications 367, 674-9. NAKAO, A., KACZOROWSKI, D. J., ZUCKERBRAUN, B. S., LEI, J., FALEO, G., DEGUCHI, K., MCCURRY, K. R., BILLIAR, T. R. & KANNO, S. (2008).

- Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 375, 346-350.SATO, Y., KAJIYAMA, S., AMANO, A., KONDO, Y., SASAKI, T., HANDA, S., TAKAHASHI, R., FUKUI, M., HASEGAWA, G., NAKAMURA, N., FUJINAWA, H., MORI, T., OHTA, M., OBAYASHI, H., MARUYAMA, N. & ISHIGAMI, A. (2008).

- Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters 453, 81–85.FU, Y., ITO, M., FUJITA, Y., ITO, M., ICHIHARA, M., MASUDA, A., SUZUKI, Y., MAESAWA, S., KAJITA, Y., HIRAYAMA, M., OHSAWA, I., OHTA, S. & OHNO, K. (2009).

- Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One 4, e7247.FUJITA, K., SEIKE, T., YUTSUDO, N., OHNO, M., YAMADA, H., YAMAGUCHI, H., SAKUMI, K., YAMAKAWA, Y., KIDO, M. A., TAKAKI, A., KATAFUCHI, T., TANAKA, Y., NAKABEPPU, Y. & NODA, M. (2009).

- Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research 65, S124-S124. KUROKI, C., TOKUMARU, O., OGATA, K., KOGA, H. & YOKOI, I. (2009).

-Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. NAGATA, K., NAKASHIMA-KAMIMURA, N., MIKAMI, T., OHSAWA, I. & OHTA, S. (2009).

Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. BARI, F., OLAH, O., NEMETH, I., HUGYECZ, M. & DOMOKI, F. (2010).

Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition 46, 269-276.GU, Y., HUANG, C. S., INOUE, T., YAMASHITA, T., ISHIDA, T., KANG, K. M. & NAKAO, A. (2010).

-Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research 1354, 196-205. JI, X., LIU, W., XIE, K., QU, Y., CHAO, X., CHEN, T., ZHOU, J. & FEI, Z. (2010).

-Hydrogen-rich saline improves memory function in a rat model of amyloid-beta- induced Alzheimer’s disease by reduction of oxidative stress.LI, J., WANG, C., ZHANG, J. H., CAI, J. M., CAO, Y. P. & SUN, X. J. (2010).

-Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. UEDA, Y., NAKAJIMA, A. & OIKAWA, T. (2010).

Neuroprotective effects of hydrogen gas on brain in three types of stress models: : a P-31 NMR and ESR study. Neuroscience Research 68, E320- E320

-Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research 1, 7. ECKERMANN, J. M., CHEN, W., JADHAV, V., HSU, F. P., COLOHAN, A. R., TANG, J. & ZHANG, J. H. (2011)

Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research 1404, 31-8.HUGYECZ, M., MRACSKO, E., HERTELENDY, P., FARKAS, E., DOMOKI, F. & BARI, F. (2011).

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